01 - Combine buttermilk and hot sauce in a large bowl. Add chicken pieces, turning to coat thoroughly. Cover and refrigerate for at least 2 hours, or overnight for maximum flavor penetration.
02 - Preheat oven to 425°F. Whisk flour, baking powder, baking soda, and salt in a large bowl. Cut in cold butter using a pastry blender or fingers until mixture resembles coarse crumbs. Stir in buttermilk just until dough comes together.
03 - Turn dough onto a floured surface and pat to 1-inch thickness. Cut into rounds with a biscuit cutter. Place on a parchment-lined baking sheet. Brush tops with extra buttermilk. Bake for 12–15 minutes until golden brown.
04 - Mix flour, paprika, cayenne, garlic powder, onion powder, oregano, thyme, salt, and black pepper in a shallow dish until well combined.
05 - Remove chicken from marinade, allowing excess to drip off. Dredge each piece in seasoned flour, pressing firmly to adhere coating. Place on a wire rack and rest for 10 minutes to set the breading.
06 - Heat 2 inches of vegetable oil in a heavy skillet to 350°F. Fry chicken in batches, turning occasionally, until golden brown and cooked through to an internal temperature of 165°F, approximately 15–18 minutes. Drain on a wire rack.
07 - Arrange fried chicken and warm biscuits on a serving platter. Serve immediately while hot.